Zymostenol

A precursor of cholesterol

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库存: 现货

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数量
5mg

￥1625.00

1300.00

- +
10mg

￥2937.00

2350.00

- +
25mg

￥6487.00

5190.00

- +
50mg

￥12050.00

9640.00

- +

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金额: ￥0.00

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Background

Zymostenol is a late-stage precursor in the biosynthesis of cholesterol. It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1 µM in a RORγ coactivator recruitment assay in the presence of ursolic acid . It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro. Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen , which are associated with cell differentiation and a protective type of autophagy. When used alone at a concentration of 20 µM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.