βARK1 Inhibitor

An inhibitor of GRK2/βARK1

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库存: 现货

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数量
1mg

￥412.00

330.00

- +
5mg

￥1675.00

1340.00

- +
10mg

￥2800.00

2240.00

- +
25mg

￥6100.00

4880.00

- +

已选 0 种 0 瓶

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货号: ajci64452
CAS: 24269-96-3
别名: 呋喃妥因-13C3
分子式: C12H9NO6
分子量: 263.2
纯度: >98%
溶解度: DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL,Ethanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

βARK1 inhibitor is an inhibitor of G protein-coupled receptor kinase 2/β-adrenergic receptor kinase 1 (GRK2/βARK1; IC50 = 126 µM). It is selective for GRK2/βARK1 over PKA at concentrations up to 1 mM. βARK1 inhibitor decreases systolic blood pressure in ob/ob and nicotinamide plus streptozotocin-induced mouse models of type 2 diabetes when administered at a dose of 200 µg/kg. It also improves clonidine-induced relaxation of precontracted isolated aortic rings and improves glucose tolerance in the ob/ob mouse model. βARK1 inhibitor inhibits dopamine inhibition reversal (DIR) induced by serotonin or neurotensin in the rat ventral tegmental area in vitro.