Cafestol

A natural diterpene which increases serum cholesterol

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库存: 现货

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5mg

￥700.00

560.00

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10mg

￥1012.00

810.00

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50mg

￥3012.00

2410.00

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货号: ajci64946
CAS: 469-83-0
别名: 咖啡醇
分子式: C20H28O3
分子量: 316.4
纯度: >98%
溶解度: DMF: 12 mg/ml,DMF:PBS (pH 7.2) (1:50): 0.02 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].

参考文献:
[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32.