2,3-dinor-8-iso Prostaglandin F2α

A metabolite of 8-iso PGF2α

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25ug

￥1337.00

1070.00

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50ug

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100ug

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货号: ajci65074
CAS: 221664-05-7
别名: 前列腺素
分子式: C18H30O5
分子量: 326.4
纯度: >98%
溶解度: DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation. 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats. In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α. Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α. 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml. Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.