5'-Ethynyl-2'-deoxycytidine

A nucleoside analog

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库存: 现货

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1mg

￥500.00

400.00

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5mg

￥1887.00

1510.00

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10mg

￥3525.00

2820.00

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25mg

￥7475.00

5980.00

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货号: ajci65524
CAS: 69075-47-4
别名: 5-乙炔基-2'-脱氧胞苷
分子式: C11H13N3O4
分子量: 251.2
纯度: >98%
溶解度: DMF: 5 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at 2-8°C, protect from light, stored under nitrogen
库存: 现货

Background

5'-Ethynyl-2'-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1',2'-3H]deoxyuridine over [CH3-3H]deoxythymidine in PRK cells (ID50s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.