Oxyphenbutazone

An NSAID

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库存: 现货

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包装

价格

促销价

数量
1mg

￥375.00

300.00

- +
5mg

￥850.00

680.00

- +
10mg

￥1337.00

1070.00

- +
25mg

￥2575.00

2060.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci65544
CAS: 129-20-4
别名: 羟布宗
分子式: C19H20N2O3
分子量: 324.4
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.5 m/ml,Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Oxyphenbutazone is a metabolite of phenylbutazone . Both compounds were identified as having anti-inflammatory effects in early studies, and, as a result, are considered NSAIDs. Interestingly, the effects of the two compounds in animal models differ, with phenylbutazone having anti-inflammatory effects in rheumatic diseases and oxyphenbutazone reducing edema in certain types of acute inflammation. Oxyphenbutazone is a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits organic anion transporter 1 (Ki = 32 µM). It inhibits the growth of MH60/BSF-2 cells induced by IL-6 (IC50 = 7.5 µM). Oxyphenbutazone stimulates neurite outgrowth at 1.5 µM and sensitizes M. tuberculosis to antimicrobials.