(R)-(+)-Pulegone

A monoterpene with anti-inflammatory activity

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5mg

￥425.00

340.00

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货号: ajci65634
CAS: 89-82-7
别名: 胡薄荷酮
分子式: C10H16O
分子量: 152.2
纯度: >98%
溶解度: Chloroform: Soluble,Ethanol: Soluble
储存: Store at -20°C
库存: 现货

Background

(R)-(+)-Pulegone is a monoterpene that has been found in a variety of plants, including Labiatae species and M. verticillata, and has anti-inflammatory activity. It stimulates proliferation of lymphocytes derived from allergic patients in vitro when used at concentrations of 6.2 and 62 µg/ml and reduces the level of IL-13 in supernatant from lymphocyte cultures when used at a concentration of 62 µg/ml. (R)-(+)-Pulegone decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at doses ranging from 0.1 to 10 µM. It also decreases serum IgE levels and skin protein levels of nerve growth factor, IFN-γ, IL-6, IL-1β, TNF-α, NF-κB, phosphorylated ERK1/2, and phosphorylated JNK.