2-Amino-3-methylimidazo[4,5-f]quinoline

A food-derived carcinogen

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库存: 现货

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10mg

￥600.00

480.00

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50mg

￥2712.00

2170.00

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100mg

￥4762.00

3810.00

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货号: ajci65656
CAS: 76180-96-6
别名: 2-氨基-3-甲基-3H-咪唑并喹啉
分子式: C11H10N4
分子量: 198.2
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 15 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke. In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.