3-deoxy Glucosone

A precursor for advanced glycation endproducts

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库存: 现货

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1mg

￥1012.00

810.00

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5mg

￥3775.00

3020.00

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10mg

￥6550.00

5240.00

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货号: ajci65730
CAS: 4084-27-9
别名: 3-脱氧葡萄糖醛酮,2-keto-3-Deoxyglucose
分子式: C6H10O5
分子量: 162.1
纯度: >98%
溶解度: 1mg/mL in ethanol, 20mg/mL in DMSO, or in DMF
储存: Store at -20°C,protect from light
库存: 现货

Background

3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.[1] [2]I[3] t is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.[4]? 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.

Reference:
[1]. Yamada, H., Miyata, S., Igaki, N., et al. Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. The Journal of Biological Chemisty 269(32), 20275-20280 (1994).
[2]. Kusunoki, H., Miyata, S., Ohara, T., et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care 26(6), 1889-1894 (2003).
[3]. Niwa, T., and Tsukushi, S. 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int.Suppl. 78, S37-S41 (2001).
[4]. Thornalley, P.J., Langborg, A., and Minhas, H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemistry Journal 344(Pt 1), 109-116 (1999).