Agnuside

An iridoid glycoside with diverse biological activities

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库存: 现货

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1mg

￥700.00

560.00

- +
5mg

￥1925.00

1540.00

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10mg

￥3175.00

2540.00

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25mg

￥6975.00

5580.00

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货号: ajci65742
CAS: 11027-63-7
别名: 穗花牡荆苷; Agnoside
分子式: C22H26O11
分子量: 466.4
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Agnuside is an iridoid glycoside originally isolated from V. rotundifolia fruit that has diverse biological activities. It inhibits COX-2 with an IC50 value of 0.026 mg/ml but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant . In vivo, agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia. It also suppresses production of the pro-inflammatory mediators prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.