SRS11-92

A ferroptosis inhibitor

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库存: 现货

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1mg

￥262.00

210.00

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5mg

￥1225.00

980.00

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10mg

￥2087.00

1670.00

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25mg

￥4262.00

3410.00

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货号: ajci66086
CAS: 1467047-25-1
别名: AA9
分子式: C22H28N2O2
分子量: 352.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1 . It inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM). SRS11-92 (2 µM) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. It also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington's disease in a concentration-dependent manner. SRS11-92 (3 µM) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner. It is selectively toxic to L. major promastigotes (LD50 = 3.34 µM) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 µM.