Inflachromene

An anti-inflammatory HMGB inhibitor

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库存: 现货

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5mg

￥2037.00

1630.00

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10mg

￥3475.00

2780.00

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25mg

￥8125.00

6500.00

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货号: ajci66090
CAS: 908568-01-4
别名: 炎性色素,ICM
分子式: C21H19N3O4
分子量: 377.4
纯度: >98%
溶解度: 2.5mg/mL in ethanol, 30mg/mL in DMSO, or in DMF
储存: Store at -20°C
库存: 现货

Background

Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.[1] It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.[2]

Reference:
[1]. Lee, S., Nam, Y., Koo, J.Y., et al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat. Chem. Biol. 10(12), 1055-1060 (2014).
[2]. Cho, W., Koo, J.Y., Park, Y., et al. Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents. J. Med. Chem. 60(1), 170-179 (2017).