8-Hydroxy-2'-deoxyguanosine

Product of oxidative damage to DNA

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1mg

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5mg

￥1425.00

1140.00

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10mg

￥2312.00

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25mg

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50mg

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货号: ajci66094
CAS: 88847-89-6
别名: 8-OH-脱氧鸟嘌呤,8-OHdG
分子式: C10H13N5O5
分子量: 283.2
纯度: >98%
溶解度: 0.1 M HCl: >10 mg/ml,DMF: 30 mg/ml,DMSO: 20 mg/ml,PBS pH 7.2: 3 mg/ml
储存: Store at -20°C
库存: 现货

Background

8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons[1].

参考文献:
[1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.