S-trityl-L-Cysteine

An inhibitor of Eg5

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库存: 现货

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1g

￥287.00

230.00

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5g

￥975.00

780.00

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10g

￥1787.00

1430.00

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货号: ajci66106
CAS: 2799-07-7
别名: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine
分子式: C22H21NO2S
分子量: 363.5
纯度: >98%
溶解度: DMSO: slightly soluble,Methanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 µM) and in mouse xenograft models.