Maresin 1

A specialized pro-resolving mediator

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货号: ajci66200
CAS: 1268720-28-0
别名: 7(R)MaR1, 7(R)Maresin 1
分子式: C22H32O4
分子量: 360.5
纯度: >98%
溶解度: 50mg/mL in Ethanol; 50mg/mL in DMSO; 50mg/mL in DMF; PBS (pH 7.2): 0.05 mg/ml
储存: Store at -80°C, protect from light
库存: 现货

Background

Docosahexaenoic acid (DHA) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1],[2] Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).[3] Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.[4]

Reference:
[1]. Su, H.-M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J. Nutr. Biochem. 21(5), 364-373 (2010).
[2]. Wu, T.C., and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatr. Neonatol. 50(4), 135-142 (2009).
[3]. Serhan, C.N., Yang, R., Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J. Exp. Med. 206(1), 15-23 (2009).
[4]. Serhan, C. . (2007).