15-keto Latanoprost (free acid)

An analytical standard

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库存: 现货

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1mg

￥1425.00

1140.00

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5mg

￥6375.00

5100.00

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10mg

￥11337.00

9070.00

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货号: ajci66220
CAS: 369585-22-8
别名: 15-酮基拉坦前列素酸
分子式: C23H32O5
分子量: 388.5
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 33 mg/ml,DMSO:PBS (1:1): 500 μ g/ml,Ethanol: 50 mg/ml
储存: Store at -20°C
库存: 现货

Background

15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 µg/eye.