4'-O-methyl Quercetin

A flavonoid with anticancer and antiplasmodial activity

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥637.00

510.00

- +
1mg

￥1225.00

980.00

- +
5mg

￥3075.00

2460.00

- +
10mg

￥5125.00

4100.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci66248
CAS: 603-61-2
别名: 柽柳黄素,4'-O-Methyl Quercetin
分子式: C16H12O7
分子量: 316.3
纯度: >98%
溶解度: DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4'-O-methyl Quercetin is a major metabolite of quercetin that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).