(6S)-Tetrahydrofolic Acid

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25mg

￥1675.00

1340.00

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50mg

￥2909.00

2327.00

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100mg

￥5239.00

4191.00

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Background:

(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid , a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. ¹(6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.² (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.³

参考文献：

1. Ragsdale, S.W. Catalysis of methyl group transfers involving tetrahydrofolate and B12. Vitam. Horm. 79, 293-324 (2008).

2. Sato, J.K., Newman, E.M., and Moran, R.G. Preparation of (6R)-tetrahydrofolic acid and (6R)-5-formyltetrahydrofolic acid of high stereochemical purity. Anal. Biochem. 154(2), 516-524 (1986).

3. Nygren-Babol, L., Sternesj?, ?., J?gerstad, M., et al. Affinity and rate constants for interactions of bovine folate-binding protein and folate derivatives determined by optical biosensor technology. Effect of stereoselectivity. J. Agric. Food. Chem. 53(13), 5473-5478 (2005).