Decursinol angelate

A pyranocoumarin with diverse biological activities

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库存: 现货

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数量
1mg

￥300.00

240.00

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5mg

￥925.00

740.00

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10mg

￥1575.00

1260.00

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货号: ajci66544
CAS: 130848-06-5
别名: 紫花前胡醇当归酯；紫花前胡醇当归酸酯
分子式: C19H20O5
分子量: 328.36
纯度: >98%
溶解度: DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. gigas and has diverse biological activities.^1,2,3,4,5 It inhibits the growth of K562, HL-60, KG-1, SK-BR-3, AGS, A549, HeLa, HepG2, and G-361 cancer cells (ED₅₀s = 24-56 μM) and decreases estrogen-stimulated growth of MCF-7 breast cancer cells in a concentration-dependent manner via decreased estrogen receptor α (ERα) protein levels and signaling activity.^1,2 Decursinol angelate (30 μM) activates PKC purified from rat brain.¹ It selectively inhibits the cytochrome P450 (CYP) isoform CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (K_is = 67.56, 872.5, and 853.9 μM, respectively).³ Decursinol angelate (0.01-10 μM) reduces cytotoxicity and malondialdehyde (MDA) production induced by amyloid-β (23-35) (Aβ25-35) and increases superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in PC12 cells.⁴ In mice, decursinol angelate (200 mg/kg) has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing as well as decreases production of the pro-inflammatory cytokines TNF-α and IL-1β.⁵

1.Ahn, K.-S., Sim, W.-S., Lee, I.-K., et al.Decursinol angelate: A cytotoxic and protein kinase C activating agent from the root of Angelica gigasPlanta Med.63(4)360-361(1997) 2.Jiang, C., Guo, J., Wang, Z., et al.Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cellsBreast Cancer Res.9(6)R77(2007) 3.Abd El-Aty, A.M., Shah, S.S., Kim, B.M., et al.In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomesArch. Pharm. Res.31(11)1425-1435(2008) 4.Li, L., Li, W., Jung, S.-W., et al.Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: The role of Nrf2 and antioxidant enzymesBiosci. Biotech. Biochem.75(3)343-342(2011) 5.Choi, S.-S., Han, K.-J., Lee, J.-K., et al.Antinociceptive mechanisms of orally administered decursinol in the mouseLife Sci.73(4)471-485(2003)