Pirlindole

A selective and reversible MAO-A inhibitor

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库存: 现货

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数量
5mg

￥1187.00

950.00

- +
10mg

￥2237.00

1790.00

- +
25mg

￥5275.00

4220.00

- +
50mg

￥9950.00

7960.00

- +

已选 0 种 0 瓶

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Background

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.