(±)-α-CMBHC

A metabolite of (±)-α-tocopherol

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库存: 现货

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数量
1mg

￥637.00

510.00

- +
5mg

￥2887.00

2310.00

- +
10mg

￥5087.00

4070.00

- +
25mg

￥11150.00

8920.00

- +

已选 0 种 0 瓶

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货号: ajci66766
CAS: 7083-09-2
别名:
分子式: C19H28O4
分子量: 320.4
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.15 mg/ml
储存: Store at -20°C
库存: 现货

Background

Vitamin E is a well known antioxidant that exists in eight natural forms: four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ). α-Tocopherol is the major lipid soluble antioxidant in vivo and protects against lipid peroxidation. α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation. α-CMBHC is the longer side-chain precursor of α-CEHC and a minor metabolite of α-tocopherol. HepG2 cells release α-CEHC, α-CMBHC, and α-CMHHC into the medium when treated with all rac α-tocopherol. Pretreatment of Hep-G2 cells with rifampicin, an inducer of the CYP3A family of cytochrome P450s, results in a 5-fold increase in α-CEHC. This indicates that metabolism of α-tocopherol proceeds by initial ω-oxidation to precursors of α-CMBHC followed by β-oxidation to shorter chain metabolites such as α-CEHC.