N-acetyl-D-Glucosamine

Monosaccharide derivative of glucose

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库存: 现货

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500mg

￥125.00

100.00

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1g

￥262.00

210.00

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5g

￥1137.00

910.00

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10g

￥1975.00

1580.00

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货号: ajci66808
CAS: 7512-17-6
别名: N-乙酰-D-氨基葡萄糖; N-Acetyl-2-amino-2-deoxy-D-glucose
分子式: C8H15NO6
分子量: 221.2
纯度: >98%
溶解度: ≤10mg/ml in DMSO;0.25mg/ml in dimethyl formamide
储存: Store at -20°C, stored under nitrogen
库存: 现货

Background

N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc. Levels of O-GlcNAcylation proteins from Alzheimer’s disease brain extracts are decreased as compared to that in controls, suggesting that release of GlcNAc may contribute to pathogenesis. In E. coli, GlcNAc induces the expression of multidrug exporter genes, indicating that this sugar can alter gene expression. GlcNAc is also the monomeric unit of chitin, which is found in fungi and many invertebrates, including crustaceans, insects, and nematodes. For this reason, chemicals that inhibit the incorporation of GlcNAc into chitin are cytotoxic to these organisms.