N-Acetyl-D-mannosamine monohydrate

A precusor of sialic acid

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100mg

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货号: ajci66810
CAS: 7772-94-3
别名: N-乙酰-D-甘露糖胺,Cyclic ManNAc
分子式: C8H15NO6
分子量: 221.21
纯度: >98%
溶解度: DMF: 2 mg/ml,DMSO: 5 mg/ml,Ethanol: 0.2 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition as well as the formation and progression of tumors.¹ Disruption of sialic acid biosynthesis can result in severe glomerular proteinuria or neuromuscular disorders such as hereditary inclusion body myopathy (HIBM).² N-Acetyl-D-mannosamine (ManNAc) is the precursor of all physiological sialic acids. Intraperitoneal injection of ManNAc twice daily at 1,000 mg/kg in C57BL/6 mice for 13 days leads to increased sialylation in kidney, liver, blood cells, brain, spinal cord, muscle, heart, lung, and spleen.³ ManNAc reverses hyposialylation and improves glomerular integrity in GneM712T/M712T mice whose key enzyme for sialic acid production has been deleted and may prove therapeutic in the treatment of HIBM.²

1.Schwarzkopf, M., Knobeloch, K.P., Rohde, E., et al.Sialylation is essential for early development in miceProc. Natl. Acad. Sci. USA99(8)5267-5270(2002) 2.Galeano, B., Klootwijk, R., Manoli, I., et al.Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamineJ. Clin. Invest.117(6)1585-1594(2007) 3.Gagiannis, D., Gossrau, R., Reutter, W., et al.Engineering the sialic acid in organs of mice using N-propanoylmannosamineBiochim. Biophys. Acta1770297-306(2007)