δ12-Prostaglandin D2

A chemical decomposition product of PGD2

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库存: 现货

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数量
500ug

￥787.00

630.00

- +
1mg

￥1487.00

1190.00

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5mg

￥6237.00

4990.00

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10mg

￥10925.00

8740.00

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货号: ajci67104
CAS: 64072-89-5
别名: Δ12PGD2
分子式: C20H32O5
分子量: 352.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. δ12-PGD2 is one of the initial chemical decomposition products of PGD2. δ12-PGD2 is an intermediate in the pathway leading to δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.