Atomoxetine

Atomoxetine (Tomoxetine) 是一种选择性去甲肾上腺素再摄取抑制剂，对去甲肾上腺素 (NE)、5-羟色胺 (5-HT) 和多巴胺 (DA) 转运蛋白的 Ki 值分别为 5、77 和 1451 nM。

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库存: 现货

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促销价

数量
5mg

￥1150.00

920.00

- +
10mg

￥2037.00

1630.00

- +
25mg

￥4500.00

3600.00

- +
50mg

￥6775.00

5420.00

- +

已选 0 种 0 瓶

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Background

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia. Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.