(S)-3'-amino Blebbistatin

A more stable form of (–)-blebbistatin

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库存: 现货

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500ug

￥2037.00

1630.00

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1mg

￥3862.00

3090.00

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5mg

￥18112.00

14490.00

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货号: ajci67356
CAS: 2097141-18-7
别名: (-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin
分子式: C18H17N3O2
分子量: 307.3
纯度: >98%
溶解度: DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-amino group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-amino Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.