Curcumenol

A sesquiterpene

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库存: 现货

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数量
1mg

￥337.00

270.00

- +
5mg

￥775.00

620.00

- +
10mg

￥1225.00

980.00

- +
25mg

￥2550.00

2040.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci67464
CAS: 19431-84-6
别名: 莪术醇,(+)-Curcumenol
分子式: C15H22O2
分子量: 234.3
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 0.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2].

参考文献:
[1]. Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6.
[2]. Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9.