(S)-nitro-Blebbistatin

A more stable form of (–)-blebbistatin

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库存: 现货

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1mg

￥1962.00

1570.00

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5mg

￥7800.00

6240.00

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10mg

￥12175.00

9740.00

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25mg

￥20287.00

16230.00

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货号: ajci67720
CAS: 856925-75-2
别名: S(-)7Desmethyl8nitro Blebbistatin
分子式: C17H13N3O4
分子量: 323.3
纯度: >98%
溶解度: DMF: 16 mg/ml,DMSO: 16 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.