15-keto Fluprostenol isopropyl ester

A potential metabolite of travoprost

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库存: 现货

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1mg

￥950.00

760.00

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5mg

￥4212.00

3370.00

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10mg

￥6887.00

5510.00

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25mg

￥14300.00

11440.00

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货号: ajci68108
CAS: 404830-45-1
别名: 15-KETO-曲伏前列素,15-Keto Fluprostenol isopropyl ester
分子式: C26H33F3O6
分子量: 498.5
纯度: >98%
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 16 mg/ml
储存: Store at -20°C
库存: 现货

Background

Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response. The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.