15-keto Latanoprost

An analytical standard

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥1212.00

970.00

- +
5mg

￥5450.00

4360.00

- +
10mg

￥9687.00

7750.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci68110
CAS: 135646-98-9
别名: 15-酮拉坦前列素
分子式: C26H38O5
分子量: 430.6
纯度: >98%
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,DMSO:PBS (1:12): 80 μ g/ml,Ethanol: 100 mg/ml
储存: Store at -20°C
库存: 现货

Background

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where β-oxidation is reduced.