2,4-Pyridinedicarboxylic Acid (hydrate)

An inhibitor of 2-oxoglutarate-dependent enzymes

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库存: 现货

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1g

￥512.00

410.00

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5g

￥2062.00

1650.00

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货号: ajci68392
CAS: 207671-42-9
别名: 2,4-吡啶二羧酸
分子式: C7H5NO4?H2O
分子量: 185.1
纯度: >98%
溶解度: DMSO: 1.4 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存: Store at -20°C
库存: 现货

Background

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.