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  • 3-Aminopropylphosphonic Acid
3-Aminopropylphosphonic Acid的可视化放大

3-Aminopropylphosphonic Acid

A partial agonist of GABAB receptors

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3-Aminopropylphosphonic Acid的二维码
  • 库存: 现货
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  • 包装
    价格
    促销价
    数量
  • 100mg
    ￥1012.00
    810.00
    - +
  • 250mg
    ￥2012.00
    1610.00
    - +
  • 500mg
    ￥3287.00
    2630.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci68738
  • CAS: 13138-33-5
  • 别名: 3-氨基丙烷-1-磷酸
  • 分子式: C3H10NO3P
  • 分子量: 139.1
  • 纯度: >98%
  • 溶解度: DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.

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