4-(2,2,3-Trimethylcyclopentyl)butanoic Acid

An hTAS2R31 and hTAS2R43 antagonist

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库存: 现货

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1mg

￥575.00

460.00

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5mg

￥2600.00

2080.00

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10mg

￥4587.00

3670.00

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货号: ajci68878
CAS: 957136-80-0
别名: 4-(2,2,3-三甲基环戊基)丁酸,GIV3727
分子式: C12H22O2
分子量: 198.3
纯度: >98%
溶解度: 25mg/mL in DMSO, 30mg/mL in DMF, 20mg/mL in Ethanol
储存: Store at -20°C
库存: 现货

Background

4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43. [1] It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively. [1] In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.[1]

Reference:
[1]. Slack, J.P., Brockhoff, A., Batram, C., et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 20(12), 1104-1109 (2010).