Amarogentin

A secoiridoid glycoside with diverse biological activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥387.00

310.00

- +
5mg

￥1012.00

810.00

- +
10mg

￥1675.00

1340.00

- +
25mg

￥3362.00

2690.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci69794
CAS: 21018-84-8
别名: 苦龙胆酯苷
分子式: C29H30O13
分子量: 586.5
纯度: >98%
溶解度: DMSO: 100 mg/ml,PBS (pH 7.2): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis when used at a concentration of 50 µM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.