A synthetic folic acid derivative
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Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index. Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.
Calcium N5-methyltetrahydrofolate
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Pemetrexed disodium hemipenta hydrate
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DL-Folinic Acid (calcium salt)
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(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
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4-Aminobenzoic Acid (sodium salt)
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Pemetrexed (sodium salt hydrate)
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