Ansatrienin A

An ansamycin antibiotic and antifungal

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库存: 现货

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1mg

￥3212.00

2570.00

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5mg

￥11937.00

9550.00

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货号: ajci69872
CAS: 82189-03-5
别名: 安三烯菌素A
分子式: C36H48N2O8
分子量: 636.8
纯度: >98%
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存: Store at -20°C
库存: 现货

Background

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .