Arachidonoyl Ethanolamide Phosphate

A water soluble prodrug analog of AEA

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库存: 现货

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250ug

￥387.00

310.00

- +
500ug

￥737.00

590.00

- +
1mg

￥1400.00

1120.00

- +
5mg

￥6237.00

4990.00

- +

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货号: ajci69920
CAS: 183323-26-4
别名: AEAP, Anandamide Phosphate
分子式: C22H38NO5P
分子量: 427.5
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as δ9-THC . Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol . The phosphate ester of AEA, AEA-P, has been tested as a water soluble prodrug version of AEA in the treatment of C6 glioma cells in vivo. Here it acts with essentially the same potency as AEA. However, when tested for inhibition of AEA binding to isolated rat brain CB1 receptors, AEA-P is about 5-fold less potent as an agonist with a Ki of about 200 nM. The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of AEA-P on the various LPA receptors have not been tested.