Arachidonoyl-1-thio-Glycerol

A chromogenic substrate for measurement of monoacylglycerol lipase activity

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库存: 现货

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1mg

￥450.00

360.00

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5mg

￥2037.00

1630.00

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10mg

￥3600.00

2880.00

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25mg

￥7900.00

6320.00

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货号: ajci69930
CAS: 1309664-54-7
别名: 1SArachidonoyl1mercapto2,3propanediol
分子式: C23H38O3S
分子量: 394.6
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:2): .25 mg/ml
储存: Store at -80°C
库存: 现货

Background

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor. It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain. Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions. Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-arachidonoyl glycerol that can be utilized for the measurement of MAGL activity. Hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB (Ellman's reagent) resulting a yellow product with an absorbance maximum at 412 nm.