Binucleine 2

An inhibitor of Drosophila Aurora B kinase

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1mg

￥712.00

570.00

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5mg

￥2712.00

2170.00

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10mg

￥5025.00

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货号: ajci70108
CAS: 220088-42-6
别名:
分子式: C13H11ClFN5
分子量: 291.7
纯度: >98%
溶解度: Chloroform: Slightly Soluble,DMSO: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 µM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 µM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 µM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.