C18 Phytoceramide (t18:0/18:0)

A bioactive sphingolipid

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5mg

￥9225.00

7380.00

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货号: ajci70346
CAS: 34354-88-6
别名: N-硬脂酰植物鞘胺醇
分子式: C36H73NO4
分子量: 584
纯度: >98%
溶解度: Chloroform:Methanol (1:1): Soluble (warmed)
储存: Store at -20°C
库存: 现货

Background

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue. Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation.