C18:1 Ceramide (d18:1/18:1(9Z))

A naturally occurring ceramide

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5mg

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货号: ajci70352
CAS: 5966-28-9
别名: N-油酰基-D-鞘氨醇,Cer(d18:1/18:1(9Z))
分子式: C36H69NO3
分子量: 563.9
纯度: >98%
溶解度: Chloroform: Soluble,DMF: 0.15 mg/ml
储存: Store at -20°C
库存: 现货

Background

C18:1 Ceramide is a naturally occurring ceramide.[1][2][3] Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.[1][2] C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer. [3]

Reference:
[1]. Sajan, M.P., Ivey, R.A., Lee, M.C., et al. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation. J. Lipid Res. 56(1), 70-80 (2015).
[2]. Rico, J.E., Bandaru, V.V., Dorskind, J.M., et al. Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation. J. Dairy Sci. 98(11), 7757-7770 (2015).
[3]. Knapp, P., Bodnar, L., B?achnio-Zabielska, A., et al. Plasma and ovarian tissue sphingolipids profiling in patients with advanced ovarian cancer. Gynecol. Oncol. 147(1), 139-144 (2017).