CAY10404

A COX-2 inhibitor

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库存: 现货

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促销价

数量
5mg

￥1225.00

980.00

- +
10mg

￥2212.00

1770.00

- +
50mg

￥7937.00

6350.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci70540
CAS: 340267-36-9
别名:
分子式: C17H12F3NO3S
分子量: 367.4
纯度: >98%
溶解度: 17mg/mL in ethanol or DMSO, 21mg/mL in DMF
储存: Store at -20°C
库存: 现货

Background

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.[1] CAY10404 is one of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM, and COX-2 IC50 is <1 nM.)[2] As a reference point, the SI of celecoxib is about 400. Thus, CAY10404 has an SI which is several logs greater than the first generation of selective COX-2 inhibitors, and is comparable to the SI of second generation selective COX-2 inhibitors, such as valdecoxib and etoricoxib.[3]

Reference：
[1.] Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys. Acta. 1209(1), 130-139 (1994).
[2]. Habeeb, A.G., Rao, P.N.P., and Knaus, E.E. Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity. Drug Development Research 51, 273-286 (2000).
[3]. Mardini, I.A., and Fitzgerald, G.A. Selective inhibitors of cyclooxygenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1(1), 30-38 (2001).