CRANAD 28

A fluorescent affinity probe for amyloid-β

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库存: 现货

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数量
500ug

￥512.00

410.00

- +
1mg

￥1000.00

800.00

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5mg

￥4100.00

3280.00

- +
10mg

￥7187.00

5750.00

- +

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货号: ajci70886
CAS: 1623747-97-6
别名:
分子式: C27H23BF2N4O2
分子量: 484.3
纯度: >98%
溶解度: DMF: 2 mg/ml,DMSO: 2 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.