CRT0066101 (hydrochloride)

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

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库存: 现货

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1mg

￥562.00

450.00

- +
5mg

￥1662.00

1330.00

- +
10mg

￥3087.00

2470.00

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货号: ajci70894
CAS: 1290629-45-6
别名:
分子式: C18H22N6O?3HCl
分子量: 447.8
纯度: >98%
溶解度: DMF: 0.1 mg/ml,DMSO: 3 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Water: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.