Cytochalasin A

Inhibitor of actin polymerization

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库存: 现货

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1mg

￥825.00

660.00

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5mg

￥3312.00

2650.00

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10mg

￥6137.00

4910.00

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货号: ajci70958
CAS: 14110-64-6
别名: 细胞松弛素A
分子式: C29H35NO5
分子量: 477.6
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:20): 0.05 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.