Desmethyl Erlotinib

A metabolite of erlotinib

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库存: 现货

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5mg

￥1475.00

1180.00

- +
10mg

￥2587.00

2070.00

- +
50mg

￥7325.00

5860.00

- +

已选 0 种 0 瓶

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货号: ajci71080
CAS: 183321-86-0
别名: 2-[[4-[(3-乙炔基苯基)氨基]-7-(2-甲氧基乙氧基)-6-喹唑啉基]氧基]乙醇,OSI-420 free base; CP-373420
分子式: C21H21N3O4
分子量: 379.4
纯度: >98%
溶解度: DMF: 50 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 25 mg/ml,Ethanol: 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 µM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 µM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.