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  • Diclofenac Acyl-β-D-Glucuronide
Diclofenac Acyl-β-D-Glucuronide的可视化放大

Diclofenac Acyl-β-D-Glucuronide

An active metabolite of diclofenac

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Diclofenac Acyl-β-D-Glucuronide的二维码
  • 库存: 现货
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  • 包装
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  • 500ug
    ￥3087.00
    2470.00
    - +
  • 1mg
    ￥5800.00
    4640.00
    - +
已选 0 种 0 瓶
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使用我司产品发表的文章

  • 货号: ajci71130
  • CAS: 64118-81-6
  • 别名: 双氯芬酸酰基-Β-D-葡糖苷酸
  • 分子式: C20H19Cl2NO8
  • 分子量: 472.3
  • 纯度: >98%
  • 溶解度: DMSO: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Diclofenac acyl-β-D-glucuronide is an active metabolite of diclofenac and the predominant metabolite in rat. Diclofenac acyl-β-D-glucuronide is acutely toxic in vitro, suggesting it may play a role in the hepatotoxicty of diclofenac in vivo. Diclofenac acyl-β-D-glucuronide binds to organic anion transporters (OATs; Km = 60.2, 8.6, 112, and 103.9 µM for OAT1-4, respectively) as well as multi-drug resistance proteins. High levels of diclofenac are found in waste water treatment plant samples, which may be due to the back-transformation of diclofenac acyl-β-D-glucuronide to diclofenac.

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