D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

A phosphoinositol for signal transduction research

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100ug

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1mg

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货号: ajci71284
CAS: 157542-47-7
别名: D-MYO-肌醇1,4,5,6-四(磷酸二氢酯)四钠盐,Ins(1,4,5,6)-P4
分子式: C6H12O18P4?4Na
分子量: 588
纯度: >98%
溶解度: 50mg/mL in water
储存: Store at -20°C
库存: 现货

Background

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]

Reference:
[1]. Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 94, 14456-14460 (1997).
[2]. DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. American Journal of Physiology.Cell Physiology 35, C429-C436 (1994).