DYn-2

A sensitive chemical reporter for protein sulfenylation in cells

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1mg

￥875.00

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5mg

￥3875.00

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10mg

￥6900.00

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25mg

￥14950.00

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货号: ajci71404
CAS: 1354630-46-8
别名: Click Tag DYn2
分子式: C11H14O2
分子量: 178.2
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.