Emtricitabine S-oxide

A potential impurity found in commercial emtricitabine preparations

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库存: 现货

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数量
1mg

￥800.00

640.00

- +
5mg

￥3600.00

2880.00

- +
10mg

￥6400.00

5120.00

- +

已选 0 种 0 瓶

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货号: ajci71442
CAS: 152128-77-3
别名: 恩曲他滨S-氧化物(非对映体混合物),Emtricitabine sulfoxide; Emtricitabine Degradant-III
分子式: C8H10FN3O4S
分子量: 263.2
纯度: >98%
溶解度: Water: heated, slightly
储存: Store at -20°C
库存: 现货

Background

Emtricitabine S-oxide (Emtricitabine sulfoxide) is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.

Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1].

参考文献:
[1]. A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.